Yamanaka factors, key to reversing aging: science

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Thanks to Yamanaka factors, the aging It is one of the processes of nature that science has achieved reverse; These elements showed a positive impact on a group of mice that were tested at the Wyss Institute, belonging to Harvard University, in the United States, but what are these strange components that could prolong the life of human beings? And animals?

Recently, in we explain to you that a group of geneticists, headed by David Sinclair, injected four Yamanaka factors (OCT4, SOX2, KLF4 and OSK) in elderly rodents, which translated into the extension of 109% of his remaining life; Not only that, it was also shown that the animals with visual impairments (a consequence of the passage of time) recovered their ocular acuity and a certain mental agility or intelligence.

With “pears and apples” we explain what the Yamanaka factors

In order to give as clear an answer as possible, we approached Aline Ramos, a family doctor at the Mexican Institute of Social Security (IMSS), who gave us an interpretation of the study done by Sinclair and Harvard University. She explained to us that the Yamanaka factors They are elements that, inserted into a cell, “give instructions” to the genetic material to be able to perform certain functions.

“Our cells are of a certain age, and by introducing the OCT4, SOX2, KLF4 and OSK subsets, they become pluripotent, so they can reproduce and could be assigned certain functions. It is almost an embryonic cell; that is to say, that it would be practically new and would be willing to carry out any task that is assigned to it”

Aline Ramos

The health professional explained that this finding represents vast possibilities of treating different conditions such as:

  • Diabetes
  • Liver failure
  • glaucoma blindness
  • Cancer

“If a patient needs a kidney transplant, but there is no donor, they could be injected Yamanaka factors and generate hepatocytes to reverse damage to the liver and kidneys”

Aline Ramos

The risks of “rejuvenation”

In the study released by the Wyss Institute it is said that the mice used for the tests did not have all the OCT4, SOX2, KLF4 and OSK subsets inserted to restore their sight; Only three could be administered, since they detected that one of them could generate a tumor in the animals.

“The risk is that reverse the aging it is that the cells become so primitive that they do not have a specific function, generating tumors”

Aline Ramos

Will aging in humans be reversed soon?

David Sinclair’s studies are still in the animal testing phase, and there has been no talk of an early application in humans because its risks are still being evaluated, so we will have to wait to see its effects in humans.

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